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FLASH GENE
Symbol PTGER4 contributors: - updated : 11-06-2011
HGNC name prostaglandin E receptor 4 (subtype EP4)
HGNC id 9596
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a seven transmembrane segments receptor (7tm_1)
HOMOLOGY
interspecies homolog to rattus Ptger4 (88.87 pc)
homolog to murine Ptger4 (88.87 pc)
Homologene
FAMILY G-protein coupled receptor 1 superfamily
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses
  • involved in the regulation of collagen type-1, MMP1 & MMP3 in human tendon fibroblasts
  • transducing Prostaglandin E2 (PGE2) signal
  • mediating IL-1beta metabolism via the p38 MAPK pathway in human tendon fibroblasts
  • may play a major role in the tendon's degenerative changes
  • directly involved in regulation of proliferation and invasion of inflammatory breast cancer cells
  • involved in mechanisms for prostaglandin E(1) actions on the cochlea
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS ossification
    PATHWAY
    metabolism
    signaling signal transduction
    p38 MAPK pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Crohn disease
    Variant & Polymorphism other
  • increasing the risk of Crohn disease
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    bloodcoagulation 
    EP4 receptor activation is a novel antithrombotic strategy
    neurosensorialear 
    local PTGER4 agonist treatment could attenuate acute sensorineural hearing loss
    ANIMAL & CELL MODELS