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FLASH GENE

Symbol

PTGER4

contributors: - updated : 11-06-2011

HGNC name	prostaglandin E receptor 4 (subtype EP4)
HGNC id	9596

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	13.00 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000958 3 - 3432 - - - 1995 7759114

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear         Homo sapiens Lymphoid/Immune lymph node       highly Nervous nerve cranial nerve     lowly Respiratory respiratory tract trachea     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Connective adipose     highly Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Blood/Hematopoietic platelet Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a seven transmembrane segments receptor (7tm_1)

HOMOLOGY

interspecies	homolog to rattus Ptger4 (88.87 pc)
	homolog to murine Ptger4 (88.87 pc)

Homologene

FAMILY

G-protein coupled receptor 1 superfamily

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses
	involved in the regulation of collagen type-1, MMP1 & MMP3 in human tendon fibroblasts
	transducing Prostaglandin E2 (PGE2) signal
	mediating IL-1beta metabolism via the p38 MAPK pathway in human tendon fibroblasts
	may play a major role in the tendon's degenerative changes
	directly involved in regulation of proliferation and invasion of inflammatory breast cancer cells
	involved in mechanisms for prostaglandin E(1) actions on the cochlea

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

ossification

PATHWAY

metabolism

signaling

signal transduction

p38 MAPK pathway

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Crohn disease

Variant & Polymorphism other	increasing the risk of Crohn disease

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed blood coagulation   EP4 receptor activation is a novel antithrombotic strategy neurosensorial ear   local PTGER4 agonist treatment could attenuate acute sensorineural hearing loss

ANIMAL & CELL MODELS