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FLASH GENE
Symbol PCDHB13 contributors: npt - updated : 09/10/2008
HGNC name protocadherin beta 13
HGNC id 8684
Location 5q31.3      Physical location : 140.593.508 - 140.596.993
Synonym name
  • protocadherin, cadherin related neuronal receptor, beta 13 in the beta cluster
    • Synonym symbol(s) PCDHVB13, PCDH-BETA13
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    text component of PCDHB@
    STRUCTURE 3.48 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure one large coding exon
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 3485 84.5 798 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • six extracellular cadherin repeats
  • a transmembrane segment
  • a cytoplasmic tail
  • one PXXP motif
  • a putative SH3 protein-binding site, lacking a constant region
    • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Pcdhb13 protocadherin beta 13
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin subfamily
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral membrane protein type 1, localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor, putatively involved in the specificity of neuronal connections
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text playing a putative role in cell-cell interactions critical in the development of the central nervous system, mediating adhesion in synaptic junctions through lack-in process
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • cytoplasmic domain putatively connecting to intermediate filaments
    • cell & other
  • cells expressing in the same protocadherin
    • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS