| basic FUNCTION
| adaptor protein, involved in cell growth and motility |
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involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 |
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playing a crucial role in the aggressiveness of human synovial sarcoma |
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play a critical role in the breakdown of adherens junctions and the spreading of sheets of epithelial cells |
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have both cytosolic and nuclear functions  |
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its nuclear compartmentalization antagonizes its cytoskeletal functions and assign a proapoptotic role to the nuclear pool of CRK |
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effector molecule for Rac1 activation that regulates cell motility |
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regulates cell migration, morphogenesis, invasion, phagocytosis, and survival |
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CRK and CRKL adaptor proteins play important roles in numerous signaling pathways, bridging tyrosine kinase substrates to downstream signaling effectors by virtue of their phosphotyrosine-binding SH2 domains and their effector-binding SH3 domains |
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CRK-MYO1C interaction, which modulates membrane dynamics by regulating RAC1 activity, is crucial for cell adhesion and spreading |
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CRK and CRKL have overlapping functions that are critical for maintaining cell structure and have critical roles in cell structure and motility by maintaining cytoskeletal integrity 0) |
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CRK, CRKL were required for effector T cell trafficking into sites of inflammation, but not for migration to lymphoid organs |
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CRK and CRKL play essential overlapping roles in fibroblast growth |
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CRK and CRKL play overlapping roles downstream of FGF signaling in order to regulate lens fiber cell elongation |
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