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FLASH GENE

Symbol

PCDHGA12

contributors: - updated : 27-09-2004

HGNC name	protocadherin gamma subfamily A, 12
HGNC id	8699

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
text	component of PCDHG@,subfamily A
STRUCTURE	82.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

the first large exon corresponding to the variable region A12 of the gamma cluster encodes the N terminal extracellular transmembrane domains, the three small last exons corresponding the constant region of the gamma cluster encode the C terminal cytoplasmic domain (identical for each protein in the cluster)

MAPPING

cloned

Y

linked

Y

status

provisional

Map	cen - PCDHGA1 - PCDHGA2 - PCDHGA3 - PCDHGB1 - PCDHGA4 - PCDHGB2 - PCDHGA5 - PCDHGB3 - PCDHGA6 - PCDHGA7 - PCDHGB4 - PCDHGA8 - PCDHGB5 - PCDHGA9 - PCDHGB6 - PCDHGA10 - PCDHGB7 - PCDHGA11 - PCDHGA12 - PCDHGC3 - PCDHGC4 - PCDHGC5 - qter
Authors	Wu (01)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed PCDHGA12 isoform 1 - - 4800 101 932 - Matsuyoshi variable region A12 and constant region of gamma cluster PCDHGA12 isoform 2 - - 2600 - 820 - Matsuyoshi variable region A12 of gamma cluster, putatively secreted

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

six extracellular cadherin repeats,a transmembrane segment and a cytoplasmic tail identical for each protein in the cluster

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Pcdhga12 protocadherin gamma subfamily A,12

intraspecies

homolog to cadherin

Homologene

FAMILY	cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
	protocadherin subfamily

CATEGORY

adhesion , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane,junction
text	integral membrane protein type I, localized at the synaptic junction

basic FUNCTION

cadherin-related neuronal receptor,putatively involved in the specificity of neuronal connections

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , nervous system

text	playing a putative role in cell-cell interactions critical in the development of the central nervous system,mediating adhesion in synaptic junctions through lack-in process

PATHWAY

metabolism

signaling

neurotransmission

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	calcium Ca2+

protein

cytoplasmic domain putatively connecting to intermediate filaments

cell & other

cells expressing in the same protocadherin

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS