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FLASH GENE
Symbol PCDHGA8 contributors: - updated : 17-05-2006
HGNC name protocadherin gamma subfamily A, 8
HGNC id 8706
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a signal peptide,six extracellular cadherin repeats,a transmembrane segment encoded by a unique exonand a cytoplasmic tail identical for each protein in the cluster
conjugated GlycoP
isoforms Precursor
HOMOLOGY
interspecies homolog to murine Pcdhga8 protocadherin gamma subfamily A,8
intraspecies homolog to cadherin
Homologene
FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin subfamily
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral membrane protein type I, localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor,putatively involved in the specificity of neuronal connections
  • playing a putative role in cell-cell interactions critical in the development of the central nervous system
  • mediating adhesion in synaptic junctions through lack-in process
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein cytoplasmic domain putatively connecting to intermediate filaments
    cell & other cells expressing the same protocadherin
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS