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FLASH GENE

Symbol

PCDHGA8

contributors: - updated : 17-05-2006

HGNC name	protocadherin gamma subfamily A, 8
HGNC id	8706

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a signal peptide,six extracellular cadherin repeats,a transmembrane segment encoded by a unique exonand a cytoplasmic tail identical for each protein in the cluster

conjugated

GlycoP

isoforms

Precursor

HOMOLOGY

interspecies

homolog to murine Pcdhga8 protocadherin gamma subfamily A,8

intraspecies

homolog to cadherin

Homologene

FAMILY	cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
	protocadherin subfamily

CATEGORY

adhesion , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane,junction
text	integral membrane protein type I, localized at the synaptic junction

basic FUNCTION	cadherin-related neuronal receptor,putatively involved in the specificity of neuronal connections
	playing a putative role in cell-cell interactions critical in the development of the central nervous system
	mediating adhesion in synaptic junctions through lack-in process

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , nervous system

PATHWAY

metabolism

signaling

neurotransmission

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	calcium Ca2+

protein

cytoplasmic domain putatively connecting to intermediate filaments

cell & other

cells expressing the same protocadherin

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS