| basic FUNCTION
| involved in special form of hippocampal synaptic plasticity (for adaptation of acquired memory flexibility to environmental changes) |
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is a very potent source of voltage-independent Ca2+ release activity  |
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binding site for the 12 kDa FK506-binding protein, encompassing the critical valine proline motif, plays a crucial role in the modulation of the Ca2+ release properties RYR3 channel, including the regulation of both global Ca2+ responses and spontaneous Ca2+ sparks |
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with SERCA2A (ATP2A2 variant A) is involved in vasoconstriction in pulmonary arterial smooth muscle (Clark 2010) |
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intracellular calcium ion release channel responsible for the release of Ca2+ from intracellular stores following transduction of many different extracellular stimuli |
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communication between transverse-tubules and sarcoplamsic reticulum |
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contraction of skeletal muscle is triggered by release of calcium ions from sarcoplasmic reticulum following depolarization of T-tubules |
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RYR1, RYR2, RYR3 strongly regulate Ca2+ influx in human T cells |
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because SOCE regulates a variety of Ca2+-dependent T cell responses, RYR1, RYR2, RYR3 are in a position to control vital T cell functions |
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RYR1, RYR2, RYR3 are important regulators of Ca2+ signaling and Ca2+-dependent functions in human immune cells, which could be potentially used as a tool for modulating immune responses |
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intracellular calcium channel responsible for rapid release of Ca(2+) from the sarcoplasmic/endoplasmic reticulum (SR/ER) to the cytoplasm, which is essential for the excitation-contraction (E-C) coupling of cardiac and skeletal muscles |
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functions to release stored endoplasmic reticulum calcium ions (Ca2+) to increase intracellular Ca2+ concentration |
