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FLASH GENE

Symbol

PCDHAC2

contributors: npt - updated : 09/10/2008

HGNC name	protocadherin alpha subfamily C, 2
HGNC id	8677

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 5684 105 1007 - Wu variable region C2, constant region of the alpha cluster variant 2 - - 2655 91.6 884 - Wu terminating downstream intron 1, putatively secreted

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six extracellular cadherin repeats
	a transmembrane segment
	a cytoplasmic tail identical for each protein in the cluster
	two PXXP motifs
	a putative SH3 protein-binding site

conjugated

GlycoP

HOMOLOGY

intraspecies

homolog to cadherin

Homologene

FAMILY	cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
	protocadherin family

CATEGORY

adhesion , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane,junction
text	integral membrane protein type 1, localized at the synaptic junction

basic FUNCTION

cadherin-related neuronal receptor, putatively involved in the specificity of neuronal connections

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , nervous system

text	playing a putative role in cell-cell interaction critical in the development of the central nervous system

PATHWAY

metabolism

signaling

neurotransmission

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein

cytoplasmic domain putatively connecting to intermediate filaments

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS