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FLASH GENE

Symbol

ATP5I

contributors: KTN/npt - updated : 04/11/2008

HGNC name	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E
HGNC id	846

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4p16.3      Physical location : 666.225 - 668.127
Synonym name	ATP synthase e chain, mitochondrial
	F1F0-ATP synthase, murine e subunit
Synonym symbol(s)	ATP5K, MGC12532
EC.number	3.6.1.14

DNA

TYPE	functioning gene
STRUCTURE	1.90 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	pter - PDE6B ,ATP5I - D4S3038 - FGFR3 - ADD1 -D4S412 - cen
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ATP5I 4 - 368 7.8 69 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       predominantly Endocrine thyroid       highly Reproductive female system breast       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately Connective adipose     moderately Epithelial secretory glandular     Muscular       moderately

cell lineage
cell lines
fluid/secretion	highly in blood

at STAGE

physiological period

fetal

Text	highly in umbilical cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to chimpanzee ATP5I (100 pc)
	homolog to cow ATP5I (88.4 pc)
	homolog to rattus Atp5i (82.1 pc)
	homolog to murine Atp5k (87 pc)
	homolog to chicken ATP5I (75.4 pc)

Homologene

FAMILY

ATPase e subunit family

CATEGORY

enzyme , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner

basic FUNCTION

involved in ATP synthesis coupled to proton transport

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

mitochondrial transport

text	H+ transport

PATHWAY

metabolism

energetic

signaling

oxydative phosphorylation

a component	constituent of mitochondrial matrix F1 segment
	component of complex V of oxidative phosphorylation (OXPHOS)

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein

cell & other

REGULATION

inhibited by

atrazine and other triazine-based compounds

Other

regulated by diet in mice

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS