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FLASH GENE
Symbol PARP4 contributors: - updated : 25-08-2005
HGNC name poly (ADP-ribose) polymerase family, member 4
HGNC id 271
Location 13q11      Physical location : 24.995.074 - 25.086.948
Synonym name
  • vault protein, 193 kDa
  • I-alpha-I related
  • ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1
    • Synonym symbol(s) KIAA0177, PH5P, P193, PARPL, VPARP, VAULT3, ADPRTL1
    EC.number 2.4.2.30
    DNA
    TYPE functioning gene
    STRUCTURE 91.00 kb     34 Exon(s)
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Respiratorylung    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an uncleavable signal peptide,lacking the DNA-binding and the automodification domains, but retaining the catalytic domain
  • a transmembrane segment
  • a SH3 ligand binding motif (SH3) in the C terminal region
    • HOMOLOGY
    interspecies homolog to C.elegans poly ADP ribose synthase
    intraspecies homolog to ADPRT
    Homologene
    FAMILY inter-alpha-inhibitor pathway superfamily poly (ADP-ribase) polymerase (PARP) family
    CATEGORY enzyme , DNA associated , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,vault
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome
    CELLULAR PROCESS nucleotide, repair
    nucleotide, genomic integrity
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism drug
    signaling
    a component component of ribonucleoprotein vault complex, likely involved in DNA repair
    INTERACTION
    DNA
    RNA
    small molecule
    protein major vault protein (MVP)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS