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FLASH GENE
Symbol PTPLA contributors: - updated : 30-06-2005
HGNC name protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
HGNC id 9639
Location 10p14-p13      Physical location : 17.631.959 - 17.659.373
Synonym name
  • protein tyrosine phosphatase-like, member a
  • cementum attachment protein
  • DNA
    TYPE functioning gene
    STRUCTURE 27.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC283071 10p14 similar to hypothetical protein 9330140G23 HSP70-4 10p14 likely ortholog of mouse heat shock protein, 70 kDa 4 SUV39H2 10p13 suppressor of variegation 3-9 homolog 2 (Drosophila) DCLRE1C 10p14-p13 DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) LOC389940 10 similar to seven transmembrane helix receptor FLJ11106 10p13 hypothetical protein FLJ11106 LOC387634 10 similar to Acyl-CoA-binding protein (ACBP) (Diazepam binding inhibitor) (DBI) (Endozepine) (EP) MGC35468 10p13 hypothetical protein MGC35468 RPP38 10p13 ribonuclease P (38kD) NMT2 10p12.33-p12.32 N-myristoyltransferase 2 LOC221061 10p13 hypothetical protein LOC221061 ITGA8 10p13 integrin, alpha 8 FLJ13397 10p13 hypothetical protein FLJ13397 PTER 10p12 phosphotriesterase related LOC389941 10 similar to Gliacolin RSU1 10p13 Ras suppressor protein 1 CUBN 10p12.1 cubilin (intrinsic factor-cobalamin receptor) DNMT2 10p15.1 DNA (cytosine-5-)-methyltransferase 2 VIM 10p13 vimentin ST8SIA-VI 10p13 alpha 2,8-sialyltransferase PTPLA 10p14-p13 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a STAM 10p14-p13 signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 LOC340843 10p13 similar to protein of unknown function LOC340893 10p13 similar to protein of unknown function MRC1 10p13 mannose receptor, C type 1 SLC39A12 10p13 solute carrier family 39 (zinc transporter), member 12 CACNB2 10p12 calcium channel, voltage-dependent, beta 2 subunit NOPD1 10p13 nucleolar protein (NOL1/NOP2/sun) and PUA domains 1 ARL8 10p13 ADP-ribosylation factor-like 8 LOC389942 10 similar to Programmed cell death protein 8, mitochondrial precursor (Apoptosis-inducing factor) LOC387635 10 similar to ubiquitin-conjugating enzyme E2 variant 1 isoform a; DNA-binding protein LOC340895 10p12.33 similar to apical early endosomal glycoprotein precursor LOC387636 10 LOC387636 PLXDC2 10p12.33 plexin domain containing 2
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Reproductivemale systemtestis   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text in the developing heart, liver, lung, skeletal muscle
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • leucine and valine rich domains
  • a N terminal nuclear localization signal (NLS)
  • a catalytic motif with a proline instead of an arginine
  • HOMOLOGY
    interspecies homolog to murine Ptpla
    Homologene
    FAMILY
    CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • playing a role in differentiation and maintenanec of tissue types (myogenesis and cardiogenesis)
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS