| basic FUNCTION
| functioning in cell adhesion and/or receptor signaling |
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may contribute to regeneration following axonal injury |
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putative cell surface receptor implicated in both the development of the nervous system and in the regeneration of the peripheral nervous system (PNS) |
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FLRT1, FLRT2, FLRT3 have a dual role, promoting FGF signalling and modulating homotypic cell adhesion  |
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FLRT proteins act potentially as regulators of FGF signalling, being induced by the signal and then able to interact with the signalling receptor, in many tissues |
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important roles for FLRT2 and FLRT3 in mediating events such as neural crest cell migration, chondrogenesis and epithelial-mesenchymal interactions during craniofacial development |
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having dual properties as regulators of cell adhesion and potentiators of fibroblast growth factor (FGF) mediated signalling |
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FLRT2 or FLRT3 are potentially required in the epicardium to promote heart morphogenesis |
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axon guidance-related factor connected to the regulation of neuronal cell outgrowth and morphogenesis |
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bifunctional role of FLRT3 in repulsive vs. adhesive cell signaling has been already detected during embryogenesis and neuronal growth, and depends on its interactions either with UNC5B or another FLRT3 expressed by adjacent cells |
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is a modulator of neurite outgrowth, axon pathfinding, and cell adhesion, which is upregulated in the dorsal horn following peripheral nerve injury |
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FLRT2, FLRT3 are required for the proper distribution of interneurons within the cortical migratory streams and for the final laminar allocation in the postnatal cortex |
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neuropathic pain induction is a novel function of FLRT3 |
