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FLASH GENE
Symbol FLRT2 contributors: mct - updated : 25-10-2018
HGNC name fibronectin leucine rich transmembrane protein 2
HGNC id 3761
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten leucine rich repeats
  • N and C terminal cysteine rich regions
  • one fibronectin-collagen-like domains
  • a transmembrane segment (TM1)
  • an intracellular tail
    • conjugated GlycoP
    HOMOLOGY
    intraspecies paralog to FLRT1
    paralog to FLRT3
    Homologene
    FAMILY
  • fibronectin leucine rich transmembrane protein (FLRT) family
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type I membrane protein
    basic FUNCTION
  • functioning in cell adhesion and/or receptor signaling
  • FLRT1, FLRT2, FLRT3 have a dual role, promoting FGF signalling and modulating homotypic cell adhesion
  • FLRT proteins act potentially as regulators of FGF signalling, being induced by the signal and then able to interact with the signalling receptor, in many tissues (
  • important roles for FLRT2 and FLRT3 in mediating events such as neural crest cell migration, chondrogenesis and epithelial-mesenchymal interactions during craniofacial development
  • having dual properties as regulators of cell adhesion and potentiators of fibroblast growth factor (FGF) mediated signalling
  • FLRT2 or FLRT3 are potentially required in the epicardium to promote heart morphogenesis
  • plays a role in mediating cell proliferation and cell-cell interactions during early chondrogenesis
  • role of FLRT2 in enhancing cell proliferation and reducing intercellular adhesion during the early stages of chondrogenesis
  • FLRT2, FLRT3 are required for the proper distribution of interneurons within the cortical migratory streams and for the final laminar allocation in the postnatal cortex
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of extracellular matrix
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with UNC5D (FLRT2/UNC5D signalling modulates cortical neuron migration)
  • UNC5D interacts with FLRT2 in cis, controlling cell adhesion in response to externally presented
  • ADGRL2 ligands, such as FLRT2, may be therapeutically exploited to interfere with cancer metastatic dissemination
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mouse embryos lacking Flrt2 expression arrest at mid-gestation owing to cardiac insufficiency