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FLASH GENE

Symbol

FLRT2

contributors: mct - updated : 25-10-2018

HGNC name	fibronectin leucine rich transmembrane protein 2
HGNC id	3761

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_013231 2 - 7185 74 660 - 1999 10644439

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine pancreas         Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	widely expressed in the developing embryo, particularly highly expressed initially in the cranial neural crest cells, and later expressed in the developing pharyngeal region

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	ten leucine rich repeats
	N and C terminal cysteine rich regions
	one fibronectin-collagen-like domains
	a transmembrane segment (TM1)
	an intracellular tail

conjugated

GlycoP

HOMOLOGY

intraspecies	paralog to FLRT1
	paralog to FLRT3

Homologene

FAMILY

fibronectin leucine rich transmembrane protein (FLRT) family

CATEGORY

adhesion , receptor membrane

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	type I membrane protein

basic FUNCTION	functioning in cell adhesion and/or receptor signaling
	FLRT1, FLRT2, FLRT3 have a dual role, promoting FGF signalling and modulating homotypic cell adhesion
	FLRT proteins act potentially as regulators of FGF signalling, being induced by the signal and then able to interact with the signalling receptor, in many tissues (
	important roles for FLRT2 and FLRT3 in mediating events such as neural crest cell migration, chondrogenesis and epithelial-mesenchymal interactions during craniofacial development
	having dual properties as regulators of cell adhesion and potentiators of fibroblast growth factor (FGF) mediated signalling
	FLRT2 or FLRT3 are potentially required in the epicardium to promote heart morphogenesis
	plays a role in mediating cell proliferation and cell-cell interactions during early chondrogenesis
	role of FLRT2 in enhancing cell proliferation and reducing intercellular adhesion during the early stages of chondrogenesis
	FLRT2, FLRT3 are required for the proper distribution of interneurons within the cortical migratory streams and for the final laminar allocation in the postnatal cortex

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

constituent of extracellular matrix

INTERACTION

DNA

RNA

small molecule

protein	interacting with UNC5D (FLRT2/UNC5D signalling modulates cortical neuron migration)
	UNC5D interacts with FLRT2 in cis, controlling cell adhesion in response to externally presented
	ADGRL2 ligands, such as FLRT2, may be therapeutically exploited to interfere with cancer metastatic dissemination

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mouse embryos lacking Flrt2 expression arrest at mid-gestation owing to cardiac insufficiency