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FLASH GENE
Symbol BARX2 contributors: mct - updated : 09-06-2012
HGNC name BARX homeobox 2
HGNC id 956
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DNA binding, helix-turn-helix protein
  • a highly conserved proline/serine/threonine domain
    • HOMOLOGY
    interspecies homolog to murine barx1
    intraspecies homolog to BARX1
    Homologene
    FAMILY
  • BAR homeobox family
    • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • maybe regulating gene expression, morphogenesis, and differentiation
  • maybe a biological factor involved in determining sensitivity or resistance to the cytotoxic effects of cisplatin
  • influencing cellular differentiation in various developmental contexts
  • regulating gene expression by binding to DNA elements containing paired TAAT motifs that are separated by a poly(T) sequence
  • BARX2 and ESR1 may coordinately regulate cell growth, survival and invasion pathways that are critical to breast cancer progression
  • cooperates with other muscle-expressed transcription factors to regulate the early cytoskeletal remodeling events that underlie efficient myoblast differentiation
  • regulates plasticity of immature myofibers and might act as a molecular switch controlling cell differentiation and proliferation
  • regulates expression of matrix metalloproteinases (MMPs) and epithelial cell migration through the extracellular matrix
  • required for FGF10-induced lacrymal gland bud elongation
  • function specific to ocular gland development
  • likely functional network involving BARX2, FGF10 and MMPs that plays an essential role in regulating branching morphogenesis of the ocular glands
  • marker for embryonic and adult myoblasts and required for normal postnatal muscle growth and repair
  • important regulator of muscle growth and repair that acts via the control of satellite cell proliferation and differentiation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BARX2 and ESR1 proteins bind to different ESR1 gene promoters and regulate the expression of alternatively spliced mRNAs that encode 66 and 46 kDa ESR1 protein isoforms
  • interacting with FGF10 (BARX2 and FGF10 cooperate in the regulation of MMPs)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in ovarian cancer (suppressor of ovarian cancer progression )
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Barx2(-/-) mice show defective lacrimal gland morphogenesis, absence of the harderian (HG), and meibomian (MG)] glands and eyelid fusion
  • mice lacking the Barx2 gene show reduced postnatal muscle growth, muscle atrophy, and defective muscle repair