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FLASH GENE
Symbol PSKH1 contributors: - updated : 11-09-2006
HGNC name protein serine kinase H1
HGNC id 9529
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 11 subdomains characteristics of the Ca2+/CaM dependent kinase family
  • a potential SH3 domain
  • a protein kinase domain
  • one nuclear localization signal (NLS)
  • four nuclear expert signalsand several phosphorylation sites
    • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus CAM kinase 1
    intraspecies homolog to CAMK1
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text brefeldin-A sensitive Golgi compartment
    basic FUNCTION
  • having intermolecular autophosphorylation activity
  • SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-SNRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing
  • involved in maintenance of the Golgi apparatus, a key organelle within the secretory pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other autophosphorylated on serine residues
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS