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FLASH GENE
Symbol PSKH1 contributors: - updated : 11-09-2006
HGNC name protein serine kinase H1
HGNC id 9529
Location 16q22.1      Physical location : 67.927.174 - 67.963.580
Synonym name serine/threonine-protein kinase H1
EC.number 2.7.1.-
DNA
TYPE functioning gene
STRUCTURE 36.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
text structure no TATA, no CAAT
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
 parathyroid   highly
 thyroid   highly
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 11 subdomains characteristics of the Ca2+/CaM dependent kinase family
  • a potential SH3 domain
  • a protein kinase domain
  • one nuclear localization signal (NLS)
  • four nuclear expert signalsand several phosphorylation sites
    • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus CAM kinase 1
    intraspecies homolog to CAMK1
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text brefeldin-A sensitive Golgi compartment
    basic FUNCTION
  • having intermolecular autophosphorylation activity
  • SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-SNRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing
  • involved in maintenance of the Golgi apparatus, a key organelle within the secretory pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other autophosphorylated on serine residues
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS