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FLASH GENE
Symbol PSMB10 contributors: mct - updated : 25-09-2024
HGNC name proteasome (prosome, macropain) subunit, beta type, 10
HGNC id 9538
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Psmb10
Homologene
FAMILY peptidase family T1b
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
  • role for the immunoproteasome (PSMB10) in vision transmission
  • PSMB8, PSMB10 regulate cytokine expression, suggesting this system represents a novel mechanism for the regulation of cytokines and cytokine signaling
  • is a novel regulator that contributes to Ang II-induced atrial fibrillation (AF)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by interferon gamma inducible
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD121 , PRAAS5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma (HCC)
    tumoral     --over  
    in Kidney Renal Clear Cell Carcinoma when compared to normal tissues, negatively impacting patient prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneoushypertension 
    inhibition of PSMB10 may represent a potential therapeutic target for treating hypertensive atrial fibrillation (AF)
    ANIMAL & CELL MODELS