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FLASH GENE
Symbol PSMB10 contributors: mct - updated : 25-09-2024
HGNC name proteasome (prosome, macropain) subunit, beta type, 10
HGNC id 9538
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
Cardiovascularheart    
Digestiveliver    
Lymphoid/Immunelymph node    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Psmb10
Homologene
FAMILY peptidase family T1b
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
  • role for the immunoproteasome (PSMB10) in vision transmission
  • PSMB8, PSMB10 regulate cytokine expression, suggesting this system represents a novel mechanism for the regulation of cytokines and cytokine signaling
  • is a novel regulator that contributes to Ang II-induced atrial fibrillation (AF)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by interferon gamma inducible
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD121 , PRAAS5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma (HCC)
    tumoral     --over  
    in Kidney Renal Clear Cell Carcinoma when compared to normal tissues, negatively impacting patient prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneoushypertension 
    inhibition of PSMB10 may represent a potential therapeutic target for treating hypertensive atrial fibrillation (AF)
    ANIMAL & CELL MODELS