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FLASH GENE

Symbol

PSMB10

contributors: mct - updated : 25-09-2024

HGNC name	proteasome (prosome, macropain) subunit, beta type, 10
HGNC id	9538

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	IMD121 Immunodeficiency 121 with autoinflammation PRAAS5 proteasome-associated autoinflammatory syndrome 5
Location	16q22.1      Physical location : 67.968.406 - 67.970.753
Synonym name	proteasome subunit MECL1
	proteasome subunit beta 10
	proteasome subunit beta-2i
Synonym symbol(s)	MECL1, LMP10, PSBA, IMD121, PRAAS5, beta2i, MGC1665, FLJ00366
EC.number	3.4.25.1

DNA

TYPE	functioning gene
STRUCTURE	2.34 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002801 8 - 977 NP_002792 - 273 - 2018 29499566

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus         Cardiovascular heart         Digestive liver         Lymphoid/Immune lymph node         Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Psmb10

Homologene

FAMILY

peptidase family T1b

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
	role for the immunoproteasome (PSMB10) in vision transmission
	PSMB8, PSMB10 regulate cytokine expression, suggesting this system represents a novel mechanism for the regulation of cytokines and cytokine signaling
	is a novel regulator that contributes to Ang II-induced atrial fibrillation (AF)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

interferon gamma inducible

ASSOCIATED DISORDERS

corresponding disease(s)

IMD121 , PRAAS5

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in hepatocellular carcinoma (HCC) tumoral     --over   in Kidney Renal Clear Cell Carcinoma when compared to normal tissues, negatively impacting patient prognosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous hypertension   inhibition of PSMB10 may represent a potential therapeutic target for treating hypertensive atrial fibrillation (AF)

ANIMAL & CELL MODELS