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FLASH GENE

Symbol

TRPM5

contributors: mct - updated : 10-12-2014

HGNC name	transient receptor potential cation channel, subfamily M, member 5
HGNC id	14323

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   dysfunction of the TRPM5 protein could be an important factor in the etiology of some forms of type 2 diabetes, where disruption of the normal pattern of secretion is observed

Susceptibility

to diabetes mellitus

Variant & Polymorphism other	common TRPM5 variants are likely to be associated with prediabetic phenotypes, and this may in turn contribute to the development of type 2 diabetes mellitus

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	knockout of Trpm5 or Plcb2 selectively expressed in taste tissue, in mice abolished sweet, amino acid, and bitter taste reception, but did not affect sour or salty tastes
	increased plasma insulin levels downregulate Trpm5 expression in pancreatic islets from leptin-deficient mouse models of type 2 diabetes