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FLASH GENE
Symbol TRPM5 contributors: mct - updated : 10-12-2014
HGNC name transient receptor potential cation channel, subfamily M, member 5
HGNC id 14323
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a TRP (EWK FHR) and a zinc finger containing alpha kinase domain
    • HOMOLOGY
    interspecies homolog to murine Trpm5
    intraspecies homolog to melastatin 1 (MLSN1)
    homolog to human TRPC7 (transient receptor potential channel ) gene 1
    homolog to TRPM4
    Homologene
    FAMILY
  • transient receptor family
  • LTrpC subfamily
  • subfamily M (melastatin)
    • CATEGORY receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing an important role in gustatory tissue, activating the taste receptors by transient calcium cation channel
  • may couple intracellular Ca2+ release to electrical activity and subsequent cellular responses
  • is essential for the detection of bitter, sweet, and amino acid tastes
  • might be involved in cholecystokinin secretion stimulated by linoleic acid in an enteroendocrine cell line
  • cation channel involved in sweet taste transduction
  • cation channel expressed in beta-cells and proposed to be involved in coupling intracellular Ca(2+) release to electrical activity and cellular responses
  • acting as an indispensable regulator of insulin secretion
  • membrane voltage initiated by TRPM5 channels is required for ATP secretion during taste reception
  • is essential for fat taste
  • TRPM2, TRPM4 and TRPM5 control insulin secretion levels by sensing intracellular Ca2+ increase, NAD metabolites, or hormone receptor activation
  • thoroughly characterized as a critical component of taste signaling and recently has been implicated in insulin release
  • monovalent cation channel activated by intracellular Ca2+
  • contributes to glucose-induced electrical activity of the beta cell and positively influences glucose-induced insulin release and glucose homeostasis
  • TRPM4, and TRPM5, are non-selective cation channels that are activated by an increase in intracellular calcium
  • TRPM4 and TRPM5 are both N-linked glycosylated at a unique site and also suggest that TRPM4/5 glycosylation seems not to be involved in channel trafficking, but mainly in their functional regulation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text ion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phospholipase C
  • TRPM5 activation by ATP couples TRPM5-mediated Na(+) entry to promote Ca(2+) uptake via a TLX2 to trigger MUC5AC secretion
    • cell & other
    REGULATION
    activated by heat
    inhibited by bitter compounds that constitutes the molecular basis of a novel mechanism of taste interactions, whereby the bitter tastant inhibits directly the sweet transduction pathway
    by physiological concentrations of Zn2+ through interaction with the pore-loop domain
    Other highly temperature-sensitive
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    dysfunction of the TRPM5 protein could be an important factor in the etiology of some forms of type 2 diabetes, where disruption of the normal pattern of secretion is observed
    Susceptibility to diabetes mellitus
    Variant & Polymorphism other
  • common TRPM5 variants are likely to be associated with prediabetic phenotypes, and this may in turn contribute to the development of type 2 diabetes mellitus
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • knockout of Trpm5 or Plcb2 selectively expressed in taste tissue, in mice abolished sweet, amino acid, and bitter taste reception, but did not affect sour or salty tastes
  • increased plasma insulin levels downregulate Trpm5 expression in pancreatic islets from leptin-deficient mouse models of type 2 diabetes