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FLASH GENE

Symbol

TRPM5

contributors: mct - updated : 10-12-2014

HGNC name	transient receptor potential cation channel, subfamily M, member 5
HGNC id	14323

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Endocrine pancreas       highly Homo sapiens Nervous brain         Homo sapiens Olfactory (smell) olfactory bulb         Homo sapiens Respiratory lung           nasopharynx       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...) Homo sapiens Olfactory epithelial cell Homo sapiens

cell lineage
cell lines	HeLa cells, Burkitt lymphoma cells
fluid/secretion

at STAGE

physiological period

fetal

Text	various tissues

IMPRINTING

maternally

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a TRP (EWK FHR) and a zinc finger containing alpha kinase domain

HOMOLOGY

interspecies

homolog to murine Trpm5

intraspecies	homolog to melastatin 1 (MLSN1)
	homolog to human TRPC7 (transient receptor potential channel ) gene 1
	homolog to TRPM4

Homologene

FAMILY	transient receptor family
	LTrpC subfamily
	subfamily M (melastatin)

CATEGORY

receptor membrane , transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	playing an important role in gustatory tissue, activating the taste receptors by transient calcium cation channel
	may couple intracellular Ca2+ release to electrical activity and subsequent cellular responses
	is essential for the detection of bitter, sweet, and amino acid tastes
	might be involved in cholecystokinin secretion stimulated by linoleic acid in an enteroendocrine cell line
	cation channel involved in sweet taste transduction
	cation channel expressed in beta-cells and proposed to be involved in coupling intracellular Ca(2+) release to electrical activity and cellular responses
	acting as an indispensable regulator of insulin secretion
	membrane voltage initiated by TRPM5 channels is required for ATP secretion during taste reception
	is essential for fat taste
	TRPM2, TRPM4 and TRPM5 control insulin secretion levels by sensing intracellular Ca2+ increase, NAD metabolites, or hormone receptor activation
	thoroughly characterized as a critical component of taste signaling and recently has been implicated in insulin release
	monovalent cation channel activated by intracellular Ca2+
	contributes to glucose-induced electrical activity of the beta cell and positively influences glucose-induced insulin release and glucose homeostasis
	TRPM4, and TRPM5, are non-selective cation channels that are activated by an increase in intracellular calcium
	TRPM4 and TRPM5 are both N-linked glycosylated at a unique site and also suggest that TRPM4/5 glycosylation seems not to be involved in channel trafficking, but mainly in their functional regulation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	ion transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	phospholipase C
	TRPM5 activation by ATP couples TRPM5-mediated Na(+) entry to promote Ca(2+) uptake via a TLX2 to trigger MUC5AC secretion

cell & other

REGULATION

activated by

heat

inhibited by	bitter compounds that constitutes the molecular basis of a novel mechanism of taste interactions, whereby the bitter tastant inhibits directly the sweet transduction pathway
	by physiological concentrations of Zn2+ through interaction with the pore-loop domain

Other

highly temperature-sensitive

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   dysfunction of the TRPM5 protein could be an important factor in the etiology of some forms of type 2 diabetes, where disruption of the normal pattern of secretion is observed

Susceptibility

to diabetes mellitus

Variant & Polymorphism other	common TRPM5 variants are likely to be associated with prediabetic phenotypes, and this may in turn contribute to the development of type 2 diabetes mellitus

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	knockout of Trpm5 or Plcb2 selectively expressed in taste tissue, in mice abolished sweet, amino acid, and bitter taste reception, but did not affect sour or salty tastes
	increased plasma insulin levels downregulate Trpm5 expression in pancreatic islets from leptin-deficient mouse models of type 2 diabetes