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FLASH GENE
Symbol CBLC contributors: mct - updated : 24-02-2015
HGNC name Cas-Br-M (murine) ecotropic retroviral transforming sequence c
HGNC id 15961
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved N-terminal tyrosine kinase binding (TKB) domain showed restricted structural flexibility upon phosphopeptide binding, and mutation in CBLC TKB augmenting this flexibility enhanced its binding to target phosphoproteins
  • a phosphotyrosine binding domain
  • a catalytic RING finger domain
  • C-terminal proline-rich domain that mediates interactions with SRC homology 3 (SH3) containing proteins
    • HOMOLOGY
    interspecies homolog to murine Cblc
    Homologene
    FAMILY
  • CBL family-adaptor protein 3
  • RING finger ubiquitin ligases family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulating intracellular signaling mediated by various tyrosine kinase
  • down-regulates receptor tyrosine kinases by conjugating ubiquitin to them, leading to receptor internalization and degradation
  • CD2AP and CBLC, constitute a checkpoint that controls the extent of RET downregulation and, thereby, the sensitivity of neurons to glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Src is a preferential target of CBLC for degradation
  • RTK negative regulatory gene
  • interacts with unphosphorylated RET and dissociates from RET after RET activation
  • TGFB1I1 is a CBLC interacting protein (binding leads to an increase in the ubiquitin ligase activity of CBLC once CBLC has been activated by SRC phosphorylation or through an activating phosphomimetic mutation)
  • PDLIM7 is a CBLC interacting protein, and binding of PDLIM7 to RET prevents CBLC recruitment to RET
  • binds wild-type and MEN2A isoforms of the receptor tyrosine kinase, RET, and enhances ubiquitination and degradation of activated RET
    • cell & other
  • EGF receptor and Fyn tyrosine kinase binding
    • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS