| Symbol
| USP18
| contributors: mct/npt - updated : 31-01-2016
|
| HGNC name
| ubiquitin specific peptidase 18
|
| HGNC id
| 12616
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
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| |
increases the resistance to oncogenic transformation by BCR-ABL | | tumoral
|
|
| --over
|
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increased in the malignant versus normal lung  | | constitutional
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|
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| loss of function
| |
induces inflammation by increasing the STAT signaling and exacerbates IFN-induced beta cell apoptosis by the mitochondrial pathway of cell death | | constitutional
|
|
| --low
|
| |
promotes up-regulation of MIR7-1, which in turn inhibits EGFR expression and the tumorigenic activity of cancer cells | |
Variant & Polymorphism
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| |
Candidate gene
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | hemopathy | | |
| novel candidate drug target for acute promyelocytic leukemia treatment | | cancer | | | |
| antineoplastic target | | cancer | | | |
| pharmacological inhibition of UBP43 may be of benefit in cancers and others diseases in which interferon is currently prescribed | | immunology | infectious | | |
| therapeutic potential of modulating USP18 levels in treating viral infection, especially for viruses sensitive to IFN signaling |
| | | |
|
| deletion of murine Usp18 causes an increase in free and conjugated Isg15 at the feto-maternal interface and results in fetal death | |
bone marrow cells in Ubp43-deficient mice exhibited hypersensitivity to interferon-alpha/beta-mediated apoptosis |
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