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FLASH GENE
Symbol MKRN3 contributors: - updated : 24-12-2005
HGNC name markorin 3, ring finger protein, 3
HGNC id 7114
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a distinctive array of zinc-finger motifs including two to four zinc fingers
  • a higly conserved RING-H2 zinc finger motif
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • mediating ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
    • CELLULAR PROCESS cell cycle
    nucleotide, transcription
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to a nuclear matrix attachment (MAR) sequence
    RNA binding
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    mapped within the commonly deleted PWS/AS region
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS