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FLASH GENE
Symbol OSBP2 contributors: mct - updated : 22-02-2008
HGNC name oxysterol binding protein 2
HGNC id 8504
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 4349 - 916 - Wyles (2007)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Reproductivemale systemtestis  highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal pleckstrin homology PH domain
  • a highly conserved OSBP-type sterol binding domain in the C terminus, that binds vimentin, cholesterol and oxysterols, and interacts with the filamentous vimentin network
    • HOMOLOGY
    Homologene
    FAMILY oxysterol binding protein family
    CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • putatively involved in the regulation of cholesterol metabolism
  • implicated in sterol-transport and/or sensing via binding to protein partners
  • could be involved in the maintenance of the undifferentiated state necessary for leukemogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS