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FLASH GENE

Symbol

OSBP2

contributors: mct - updated : 22-02-2008

HGNC name	oxysterol binding protein 2
HGNC id	8504

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	213.00 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 14 - 4349 - 916 - Wyles (2007)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen       highly Reproductive male system testis     highly Visual eye       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal pleckstrin homology PH domain
	a highly conserved OSBP-type sterol binding domain in the C terminus, that binds vimentin, cholesterol and oxysterols, and interacts with the filamentous vimentin network

HOMOLOGY

Homologene

FAMILY

oxysterol binding protein family

CATEGORY

regulatory , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	putatively involved in the regulation of cholesterol metabolism
	implicated in sterol-transport and/or sensing via binding to protein partners
	could be involved in the maintenance of the undifferentiated state necessary for leukemogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS