Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MAPK11 contributors: npt/ - updated : 10-04-2007
HGNC name mitogen-activated protein kinase 11
HGNC id 6873
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a protein kinase domain
  • a TGY dual phosphorylation site
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Mapk11 (96.7 pc)
    homolog to Drosophila p38b (67.7 pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • MAP kinase subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • phosphorylating ATF2
  • involved in the heat shock sensing mechanism
  • involved in a signal transduction pathway activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress
  • involved in the regulation of cyclin D3 levels
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text antimicrobial humoral response
    PATHWAY
    metabolism
    signaling signal transduction
    phosphotyrosine mediated pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Mg2+
  • ATP
    • protein
    cell & other
    REGULATION
    activated by phosphorylation on threonine and tyrosine by MAP2K6
    LBP and CD14 in neutrophils
    induced by proinflammatory cytokines, environmental stress
    inhibited by pyridinyl-imidazole related compounds
    Other promyelocytic leukemia gene negatively regulated the SAPK2/p38 signaling pathway by sequestering p38 from its upstream kinases
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS