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FLASH GENE
Symbol MAPK11 contributors: npt/ - updated : 10-04-2007
HGNC name mitogen-activated protein kinase 11
HGNC id 6873
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   moderately
Nervousnerve   highly
Skin/Tegumentskin   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  predominantly
cell lineage
cell lines
fluid/secretion highly in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a protein kinase domain
  • a TGY dual phosphorylation site
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Mapk11 (96.7 pc)
    homolog to Drosophila p38b (67.7 pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • MAP kinase subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • phosphorylating ATF2
  • involved in the heat shock sensing mechanism
  • involved in a signal transduction pathway activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress
  • involved in the regulation of cyclin D3 levels
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text antimicrobial humoral response
    PATHWAY
    metabolism
    signaling signal transduction
    phosphotyrosine mediated pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Mg2+
  • ATP
    • protein
    cell & other
    REGULATION
    activated by phosphorylation on threonine and tyrosine by MAP2K6
    LBP and CD14 in neutrophils
    induced by proinflammatory cytokines, environmental stress
    inhibited by pyridinyl-imidazole related compounds
    Other promyelocytic leukemia gene negatively regulated the SAPK2/p38 signaling pathway by sequestering p38 from its upstream kinases
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS