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FLASH GENE

Symbol

DNM2

contributors: mct/shn - updated : 28-11-2018

HGNC name	dynamin 2
HGNC id	2974

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DICMT1 , CNM2 , LCCS5 , SPG69

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in late-onset Alzheimer disease, results in the accumulation of APP in lipid raft-rich plasma membranes tumoral     --over   is associated with IKAROS dysregulation and may be important in the development of B- Acute Lymphoblastic Leukemia constitutional     --low   coupled with severe ventricular arrhythmias

Susceptibility

to late-onset Alzheimer disease (LOAD)

Variant & Polymorphism other	polymorphisms increasing the risk of late-onset Alzheimer disease (LOAD)

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular rythm   with its multi-ion channel targeting properties, could be a promising target for novel antiarrhythmic therapies

ANIMAL & CELL MODELS

in isolated muscle fibers from wild-type and HTZ mice, Dnm2 localized in regions of intense membrane trafficking (I-band and perinuclear region), emphasizing the pathophysiological hypothesis in which Dnm2-dependent trafficking would be altered