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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

BIK

contributors: mct/pgu - updated : 10-06-2020

HGNC name	BCL2-interacting killer (apoptosis-inducing)
HGNC id	1051

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       mutated in B-cell lymphomas tumoral   deletion     chromosomal deletions encompassing BIK locus or epigenetic silencing in cancers

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	prognostic or therapeutic marker in breast cancer patients according to the estrogen receptor alpha expression
Therapy target
	System Type Disorder Pubmed cancer     prominent target for anti-cancers drugs that inhibit proteasomal functions cancer     therapeutic molecule in gene therapy-based approaches to treat difficult cancers cancer     blocking BIK degradation has the potential to be used as an anti-cancer strategy

ANIMAL & CELL MODELS