SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,nuclear envelope
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| text
| colocalizing with cytoplasmic and nuclear membranes |
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intracytoplasmic membrane |
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single-pass membrane protein |
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predominantly localized to the endoplasmic reticulum (predominantly to the outer membrane of the endoplasmic reticulum) where it regulates BAX/BAK-dependent release of Ca2+ from the endoplasmic reticulum stores and cooperates with other BH3-only proteins such as PMAIP1 to cause rapid release of cytochrome c from mitochondria and activate apoptosis  |
| basic FUNCTION
| acting as a likely target for antiapoptotic proteins |
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inducing apoptosis through the mitochondrial pathway by mobilizing calcium from the ER to the mitochondria and remodeling the mitochondrial cristae |
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also inducing non-apoptotic cell death |
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involved in the selection of mature B cells |
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critical effector in apoptosis induced by toxins, cytokines virus infections |
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proapoptotic tumor suppressor |
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plays a critical role in promotion of anti-estrogen-induced cell death in breast cancer cells |
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has a role in both, apoptosis induction and sensitivity to oxidative stress in myeloma cells |
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inactivate BCL2 through complex formation |
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key mediator of estrogen-starvation and anti-estrogen induced apoptosis |
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stronger inducer of apoptosis than PMAIP1, and when expressed simultaneously, a combinative effect was observed |
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initiator of mitochondrial apoptosis, and its expression is induced by proapoptotic signals, including DNA damage |
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TUT1-control of BIK expression and apoptosis is regulated by nuclear PIP5K1A and PRKCD signaling |
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can be a critical mediator of melanoma cell fate determination in response to MAPK pathway inhibition |
