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FLASH GENE

Symbol

AKT3

contributors: mct - updated : 29-11-2014

HGNC name	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
HGNC id	393

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	355.35 kb     14 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	pkb gamma and pkb gamma 1

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_181690 13 - 7091 55.8 479 - Cristiano NM_181690 17 - 1584 - 465 - Cristiano

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       lowly Digestive liver       lowly Nervous brain       highly Reproductive male system testis     lowly Respiratory lung       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	highly in heart, liver, brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a SH2 and a pleckstrin (PH) homology N terminal domain
	a short alpha helical linker
	a C terminal kinase domain

HOMOLOGY

interspecies	homolog to V-akt murine thymoma viral oncogene 3
	homolog to C.elegans F28H6.1

Homologene

FAMILY

Ser/Thr protein kinase, B family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus
	intracellular,nuclear envelope
text	localized in both the nucleus and nuclear membrane

basic FUNCTION	AKT is a key regulator for cell growth, cell survival and metabolic insulin action
	involved in the regulation of diverse cellular functions such as cell proliferation, energy metabolism, and apoptosis
	AKT2 and AKT3 play an important role in the viability of human malignant glioma cells
	may oppose AKT1 in lung tumorigenesis and lung tumor progression
	AKT1 and AKT3 are essential for the proliferation of reprogrammed cells

CELLULAR PROCESS	cell life, proliferation/growth
	cell life, antiapoptosis

PHYSIOLOGICAL PROCESS

text	survival of lymphoid and other cell types

PATHWAY

metabolism

signaling

central role of PI3K/AKT signaling in vascular, limb and brain development

a component

INTERACTION

DNA

RNA

small molecule

protein	enhanced AKT2 or AKT3 activation also promotes reprogramming and coordinates with LIF to activate STAT3
	AKT3 is likely a regulator of mitochondrial dynamics in the vasculature via regulation of XPO1-dependent nuclear export

cell & other

REGULATION

activated by	growth factors via PI3K (phosphatidyl inositol 3-kinase) binding to PH domain in the antiapoptotic PI3K pathway induced by insulin growth factor 1, and maybe other
	coactivated by TCL1

ASSOCIATED DISORDERS

corresponding disease(s)

DEL1Q44 , MPPH2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in estrogen receptor-negative breast tumor tumoral       gain of function associated with the survival of melanoma cells

Susceptibility

Variant & Polymorphism

Candidate gene	for microcephaly and corpus callosum agenesis in 1qter microdeletion syndrome
Marker
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma targeting AKT2 and AKT3 may hold promise for the treatment of patients with gliomas (PMID: 20167810)

ANIMAL & CELL MODELS