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FLASH GENE
Symbol S100A2 contributors: mct/npt - updated : 10-02-2016
HGNC name S100 calcium binding protein A2
HGNC id 10492
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two calcium binding domains with an EF-hand motif
  • one S100 specific N-terminus
  • one classical C-terminus
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • S-100 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • EF-hand calcium-binding S100 protein functioning as tumor suppressor
  • calmodulin-like protein, TP53-inducible, readily oxidized in keratinocytes subjected to oxidative stress
  • playing a crucial role in the differentiation of keratinocytes
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of epidermal diffentiation complex
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • binding Zn2+ with a high affinity
    • protein
  • direct transcriptional target of TP53 homologues during keratinocyte differentiation
  • with S100A1, S100A4 and S100A6, interacting with MDM2, making the binding to MDM2 a general feature of S100 proteins
  • S100A1, S100A2, S100A6, and S100B proteins specifically interact with PPP5C-tetratricopeptide repeat (TPR) domain
    • cell & other
    REGULATION
    induced by p53
    p63 splice variant TAp63gamma
    Other regulated by both Zn2+ and Ca2+, and suggest that Zn2+ might deactivate S100A2 by inhibiting response to intracellular Ca2+ signals
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in lymph node metastases of head and neck cancer
    tumoral     --over  
    in Barrett's adenocarcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS