Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EP400 contributors: mct - updated : 01-10-2014
HGNC name E1A binding protein p400
HGNC id 11958
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an helicase ATP-binding domain
  • an helicase C-terminal domain
  • a HSA domain
  • a Myb-like domain
  • a conserved SWI3-ADA2-N-CoR-TFIIIB (SANT) domain which interact both with histone tails and with other proteins and is further implicated in both positive and negative chromatin-regulatory modifications
    • HOMOLOGY
    Homologene
    FAMILY
  • SNF2/RAD54 helicase family
  • SWI2/SNF2 family of chromatin remodeling proteins
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • may be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation
  • represses CDKN1A expression in unstressed cells, thereby allowing cell cycle progression and DNA damage-induced apoptosis
  • inhibits TP53 --> CDKN1A transcription and the development of premature senescence
  • SWI2/SNF2-related ATPase that serves as an ATP-dependent chromatin remodeling enzyme
  • represses basal CDKN1A gene expression through dual mechanisms that include the direct inhibition of KAT5 enzymatic activity and the previously described ATP-dependent positioning of H2AFZ at the promoter
  • through an ATP-dependent chromatin remodeling activity that facilitates H2AFZ deposition, acts to repress specific genes (CDKN1A) in this pathway
  • ATP-dependent chromatin-remodeling protein that catalyzes the deposition of histone variant H2A.Z into nucleosomes to regulate gene expression
  • plays a key role in cellular proliferation by controlling the expression of cell-cycle-regulatory genes
  • is a novel DNA damage response protein and EP400-mediated alterations in nucleosome and chromatin structure promote both chromatin ubiquitination and the accumulation of BRCA1 and TP53BP1 at sites of DNA damage
  • EP400 ATPase is required for DNA repair by homologous recombination (HR)
  • is important for HR-dependent processes, such as recruitment of RAD51 to DSB (a key component of HR), homology-directed repair, and survival after DNA damage
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the NuA4 histone acetyltransferase complex
  • component of the p53-p21(WAF1/CIP1/sid1) pathway, regulating the CDKN1A transcription and senescence induction program
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • interacting with MYC, an essential downstream target of E1A
  • interacting with KAT5 (KAT5 and EP400, which belongs to the Tip60 complex, are also required for DNA damage-induced apoptosis)
  • interacting with H2AFZ (required for the localization of H2AFZ, and largely colocalizes with H2AFZ at multiple promoters)
  • interaction between KAT5 and EP400 involving the SANT domain, which binds to the HAT domain of KAT5 and suppresses HAT activity
  • HDAC6 plays a major role in the modulation of KAT5-EP400 function in stem cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    EP400-PHF1, was discovered in ossifying fibromyxoid tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS