| basic FUNCTION
| may be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation |
|
represses CDKN1A expression in unstressed cells, thereby allowing cell cycle progression and DNA damage-induced apoptosis |
|
inhibits TP53 --> CDKN1A transcription and the development of premature senescence |
|
SWI2/SNF2-related ATPase that serves as an ATP-dependent chromatin remodeling enzyme  |
|
represses basal CDKN1A gene expression through dual mechanisms that include the direct inhibition of KAT5 enzymatic activity and the previously described ATP-dependent positioning of H2AFZ at the promoter |
|
through an ATP-dependent chromatin remodeling activity that facilitates H2AFZ deposition, acts to repress specific genes (CDKN1A) in this pathway |
|
ATP-dependent chromatin-remodeling protein that catalyzes the deposition of histone variant H2A.Z into nucleosomes to regulate gene expression |
|
plays a key role in cellular proliferation by controlling the expression of cell-cycle-regulatory genes |
|
is a novel DNA damage response protein and EP400-mediated alterations in nucleosome and chromatin structure promote both chromatin ubiquitination and the accumulation of BRCA1 and TP53BP1 at sites of DNA damage |
|
EP400 ATPase is required for DNA repair by homologous recombination (HR) |
|
is important for HR-dependent processes, such as recruitment of RAD51 to DSB (a key component of HR), homology-directed repair, and survival after DNA damage |
