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FLASH GENE

Symbol

STK25

contributors: mct - updated : 27-03-2018

HGNC name	serine/threonine kinase 25 (STE20 homolog, yeast)
HGNC id	11404

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Stk25-/- mice are protected against methionine and choline-deficient (MCD) diet-induced NASH, as evidenced by repressed liver steatosis, oxidative damage, inflammation, and fibrosis, whereas Stk25 transgenic mice developed a more severe nonalcoholic steatohepatitis (NASH) phenotype, compared with corresponding wild-type littermates
	transgenic mice overexpressing STK25, when challenged with a high-fat diet, develop reduced glucose tolerance and insulin sensitivity compared to wild-type siblings