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FLASH GENE

Symbol

STK25

contributors: mct - updated : 27-03-2018

HGNC name	serine/threonine kinase 25 (STE20 homolog, yeast)
HGNC id	11404

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DEL2Q37

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in conditions of excess dietary fuels associates with a shift in the metabolic balance in peripheral tissues from lipid oxidation to storage, leading to a systemic insulin resistance tumoral     --over   in prostate cancer

Susceptibility

Variant & Polymorphism

Candidate gene	pseudopseudohypoparathyroidism (PPHP)
	for brachymetaphalangism and/or obesity in the del2q37 syndrome
Marker
Therapy target
	System Type Disorder Pubmed diabete     reducing STK25 function may provide a new strategy for the treatment of patients with type 2 diabetes digestive liver   reducing STK25 function may provide a new strategy for the treatment of patients with Nonalcoholic fatty liver disease (NAFLD) metabolism     potential drug target for metabolic disease

ANIMAL & CELL MODELS

	Stk25-/- mice are protected against methionine and choline-deficient (MCD) diet-induced NASH, as evidenced by repressed liver steatosis, oxidative damage, inflammation, and fibrosis, whereas Stk25 transgenic mice developed a more severe nonalcoholic steatohepatitis (NASH) phenotype, compared with corresponding wild-type littermates
	transgenic mice overexpressing STK25, when challenged with a high-fat diet, develop reduced glucose tolerance and insulin sensitivity compared to wild-type siblings