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FLASH GENE
Symbol SALL3 contributors: shn/npt - updated : 21-05-2009
HGNC name sal-like 3 (Drosophila)
HGNC id 10527
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four conserved double zinc finger (DZF) domains containing sequences related to the SAL box domain of Drosophila
  • eight C2H2 zinc finger domains
  • four C2H2 fingers make 2 units of a DZF motif
  • a KRAB domain
    • HOMOLOGY
    interspecies ortholog to Sall3, Pan troglodytes
    ortholog to Sall3, Rattus norvegicus
    ortholog to Sall3, Mus musculus
    Homologene
    FAMILY
  • SAL family of C2H2 type zinc finger domain
  • SPALT family zinc-finger transcription factors
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for the development of nerves that are derived from the hindbrain and for the formation of adjacent branchial arch derivatives
  • may be involved in transcriptional regulation
  • involved in embryonic development
  • SALL3 is a cellular factor that inhibit the activity and the association with chromatin of DNA methyltransferase 3 alpha (DNMT3A)
  • potentially regulates the differentiation of horizontal interneurons, which form direct synaptic contacts with cone photoreceptors
  • potential factor that regulates terminal differentiation of both cone photoreceptors and their postsynaptic partners
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein DNA methyltransferase 3 alpha (DNMT3A) through its DZF motif and the PWWP domain of DNMT3A
    less readily with DNMT3B
    cell & other
    REGULATION
    induced by BMP-4
    Other inactivation of SALL3 by DNA methylation accelerates aberrant
    DNA methylation in hepatocellular carcinoma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion --low  
    in 18q del syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Sall3 homozygous mutant mice died after birth with deficiencies in cranial nerves