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FLASH GENE
Symbol SALL3 contributors: shn/npt - updated : 21-05-2009
HGNC name sal-like 3 (Drosophila)
HGNC id 10527
DNA
TYPE functioning gene
STRUCTURE 17.92 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D18S461 - D18S1122 - SALL3 - D18S1141 - D18S1095 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 4775 - 1300 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   moderately
Endocrinepancreas   moderately
Nervousbrain   lowly
Reproductivefemale systemplacenta  lowly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal moderately
cell lineage
cell lines FLC4 cells of HCC cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text brain, hippocampus, cerebellum, putamen, cortex
IMPRINTING paternally
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four conserved double zinc finger (DZF) domains containing sequences related to the SAL box domain of Drosophila
  • eight C2H2 zinc finger domains
  • four C2H2 fingers make 2 units of a DZF motif
  • a KRAB domain
  • HOMOLOGY
    interspecies ortholog to Sall3, Pan troglodytes
    ortholog to Sall3, Rattus norvegicus
    ortholog to Sall3, Mus musculus
    Homologene
    FAMILY
  • SAL family of C2H2 type zinc finger domain
  • SPALT family zinc-finger transcription factors
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for the development of nerves that are derived from the hindbrain and for the formation of adjacent branchial arch derivatives
  • may be involved in transcriptional regulation
  • involved in embryonic development
  • SALL3 is a cellular factor that inhibit the activity and the association with chromatin of DNA methyltransferase 3 alpha (DNMT3A)
  • potentially regulates the differentiation of horizontal interneurons, which form direct synaptic contacts with cone photoreceptors
  • potential factor that regulates terminal differentiation of both cone photoreceptors and their postsynaptic partners
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein DNA methyltransferase 3 alpha (DNMT3A) through its DZF motif and the PWWP domain of DNMT3A
    less readily with DNMT3B
    cell & other
    REGULATION
    induced by BMP-4
    Other inactivation of SALL3 by DNA methylation accelerates aberrant
    DNA methylation in hepatocellular carcinoma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion --low  
    in 18q del syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Sall3 homozygous mutant mice died after birth with deficiencies in cranial nerves