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FLASH GENE

Symbol

MAFF

contributors: mct/npt - updated : 04-06-2008

HGNC name	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
HGNC id	6780

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q13.1      Physical location : 38.597.938 - 38.612.515
Synonym name	transcription factor MAFF
Synonym symbol(s)	CTA-447C4.1, U-MAF

DNA

TYPE	functioning gene
STRUCTURE	14.00 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	Variants 1 and 2 encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 3 - 2382 17.7 164 - Ye (2006) variant 2 3 - 2332 17.7 164 - Ye (2006)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system breast mammary gland   highly   female system placenta     highly Urinary bladder       highly   kidney

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	in term, myometrium

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an extended leucine zipper structure but without transactivation domain
	a heptad-leucine repeat motif (viz., Leu-zipper) that may mediate protein-protein interactions to regulate transcriptional activities

HOMOLOGY

Homologene

FAMILY

V-maf musculoaponeurotic fibrosarcoma (ovarian) oncogene family protein F

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	binds to the oxytocin receptor (myometrium)
	plays crucial roles in the control of gene expression and development
	may be playing a specific role in proinflammatory cytokine-mediated control of myometrial gene expression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with MIP (activated transcription efficiently)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS