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FLASH GENE
Symbol MMRN1 contributors: mct/npt - updated : 16-05-2009
HGNC name multimerin 1
HGNC id 7178
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • RGDS coiled coil domain
  • EGF-like domain
  • C1 and C2 domains (extended MMRN1 binding site in the C1 and C2 domains is important for the storage of FV-MMRN1 complexes in platelets)(Jeimy 2008)
  • a C terminus similar to the globular domain of C1q, COLVIII, X, also containing 23 N-glycosylation sites
    • conjugated GlycoP , Other
    mono polymer heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    text Weibel-Palade bodies of endothelial cells ; alpha-granules
    basic FUNCTION
  • binds factor V in platelets, playing a role in delivering and localizing factor V onto platelets prior to prothrombinase assembly
  • released following activation and binding to endothelial cells and the extracellular matrix
  • polymeric, factor V (FV) binding protein that is stored in platelet and endothelial cell secretion granules but is undetectable in normal plasma (Jeimy 2008)
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • large soluble protein forming homotrimers and larger heteropolymers
  • EMILIN / multimerin / EMILIN2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • factor V (interact with the factor V light chain)
  • high affinity binding of FV to MMRN1 may facilitate the costorage of the two proteins in platelet alpha-granules (MMRN1 release during platelet activation may limit platelet dependent thrombin generation) (Jeimy 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS