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FLASH GENE
Symbol HSPB3 contributors: npt/ - updated : 23-08-2007
HGNC name heat shock 27kDa protein 3
HGNC id 5248
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus involved in multimerization
  • a C terminus lacking extension
    • HOMOLOGY
    interspecies homolog to murine Hspb3
    Homologene
    FAMILY
  • small heat shock (HSP20) family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inhibitor of actin polymerization
  • plays an important role in motor neuron viability (Kolb 2010)
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with HSPB2 during myogenic differentiation, but biochemical properties of the HSPB2/B3 complex are distinctly different from those of other small heat-shock proteins, indicating that the HSPB2/B3 assembly is likely to possess cellular functions other than those of its family members
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • complexing with HSPBP2 during myogenic differentiation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HMN2C
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS