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FLASH GENE
Symbol HSPB3 contributors: npt/ - updated : 23-08-2007
HGNC name heat shock 27kDa protein 3
HGNC id 5248
Corresponding disease
HMN2C neuropathy, distal hereditary motor, type IIC
Location 5q11.2      Physical location : 53.751.444 - 53.752.207
Synonym name heat shock 17 kDa protein
Synonym symbol(s) HSPL27, HSPBL4, HSB3
DNA
TYPE functioning gene
STRUCTURE 0.76 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
PELO 5q11.2 pelota homolog (Drosophila) ITGA1 5p15-p11 integrin, alpha 1 ITGA2 5q23-q31 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) MOCS2 5q11 molybdenum cofactor synthesis 2 LOC391781 5 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC391782 5 similar to ribosomal protein S19; 40S ribosomal protein S19 FST 5p11.2 follistatin NDUFS4 5q11.1 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) ASSP9 5q11-q12 argininosuccinate synthetase pseudogene 9 FLJ20051 HSPB3 5q11.2 heat shock 27kDa protein 3 SNAG1 5q11.2 sorting nexin associated golgi protein 1 LOC389290 5 LOC389290 LOC391783 5 similar to membrane-spanning proteoglycan NG2 LOC391784 5 similar to CG12279-PA LOC153134 5q11.2 hypothetical LOC153134 ESM1 5q11.2 endothelial cell-specific molecule 1 GZMK 5q11-q12 granzyme K (serine protease, granzyme 3; tryptase II) GZMA 5q11-q12 granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) FLJ37927 5q11.2 CDC20-like protein LOC345643 5q11.2 similar to geminin UNG2 5p15.2-p13.1 uracil-DNA glycosylase 2 DHX29 5q11.2 DEAH (Asp-Glu-Ala-His) box polypeptide 29 PPAP2A 5q11 phosphatidic acid phosphatase type 2A LOC379013  ring finger protein 138 pseudogene LOC391785 5 similar to Adenylate kinase isoenzyme 4, mitochondrial (ATP-AMP transphosphorylase) FLJ90709 5q11.2 hypothetical protein FLJ90709 DDX4 5q11.2-q12 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 LOC391786 5 similar to heterogeneous nuclear ribonucleoprotein H CRL3 5q11.2 gp130-like monocyte receptor IL6ST 5q11.1-q11.2 interleukin 6 signal transducer (gp130, oncostatin M receptor) FLJ11795 5q11.2 hypothetical protein FLJ11795 LOC345645 5q11.2 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC347593 5q11.2 60S ribosomal protein L26 pseudogene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 764 - 150 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmooth   
Muscularstriatumcardiac  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus involved in multimerization
  • a C terminus lacking extension
  • HOMOLOGY
    interspecies homolog to murine Hspb3
    Homologene
    FAMILY
  • small heat shock (HSP20) family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inhibitor of actin polymerization
  • plays an important role in motor neuron viability (Kolb 2010)
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with HSPB2 during myogenic differentiation, but biochemical properties of the HSPB2/B3 complex are distinctly different from those of other small heat-shock proteins, indicating that the HSPB2/B3 assembly is likely to possess cellular functions other than those of its family members
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • complexing with HSPBP2 during myogenic differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HMN2C
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS