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FLASH GENE

Symbol

ESM1

contributors: npt/ - updated : 17-09-2004

HGNC name	endothelial cell-specific molecule 1
HGNC id	3466

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	7.27 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D5S491 - IL6ST - ESM1 - CKN1 - D5S427 - qter
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 2089 18 184 - - variant 2 - - 1939 12.5 134 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Respiratory lung         Urinary kidney

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal domain cysteine-rich
	a C terminal tail free of cysteine residues

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION

chondroitin sulfate/dermatan sulfate proteoglycan promoting hepatocyte growth factor/scatter factor mitogenic activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

regulated by TNF, IL1B and IFNG

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS