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FLASH GENE
Symbol CIDEB contributors: mct - updated : 08-04-2015
HGNC name cell death-inducing DFFA-like effector b
HGNC id 1977
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CIDE-N domain
  • strong cell death-inducing activity in its C-terminal domain
    • HOMOLOGY
    Homologene
    FAMILY cell death-inducing DFF45-like effector (CIDE) protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • localization to endoplasmic reticulum (ER) and lipid droplets (LD), and also localized to the Golgi apparatus
    • basic FUNCTION
  • cell death-inducing DFFA-like effector B
  • putatively involved in apoptotic DNA fragmentation
  • inducing cell death in a caspase-dependent manner through cytochrome c release from mitochondria
  • important regulator in the development of obesity and diabetes by controlling fatty acid synthesis and VLDL secretion in hepatocytes
  • is a novel regulator in controlling cholesterol homeostasis in the liver
  • present in pancreatic beta-cells and involved in palmitate induced beta-cell apoptosis
  • CIDEB and PLIN2 play opposing roles in controlling VLDL lipidation and hepatic lipid homeostasis
  • direct requirement of CIDEB in VTV (very low density lipoprotein (VLDL) transport vesicle) formation
  • potential role in VLDL transport from the ER to the Golgi
  • mediates lipid droplet (LD) fusion, as well as very-low-density lipoprotein (VLDL) maturation
  • play a critical role in maintaining hepatic lipid homeostasis by promoting the lipidation and maturation of VLDL particles
  • plays an important role in controlling intestinal chylomicron lipidation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DFFA/DFFB complex
  • PPARGC1A plays an important role in partitioning cytoplasmic Triglycerdes toward the VLDL secretory compartments and promoting VLDL secretion via transcriptional induction of CIDEB
  • interacts with APOB100 in the ER, whereas it does not interact with albumin, which is excluded from the VTV
  • CIDEB is an essential cofactor for hepatitis C virus (HCV) entry into hepatocytes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetemetabolic syndrom 
    could serve as an important therapeutical target for the treatment of atherosclerosis and cardiovascular diseases
    ANIMAL & CELL MODELS
  • mice with Cideb deficiency exhibited reduced intestinal chylomicron-TG secretion and increased lipid accumulation in the enterocytes