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FLASH GENE

Symbol

CIDEB

contributors: mct - updated : 08-04-2015

HGNC name	cell death-inducing DFFA-like effector b
HGNC id	1977

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	6.19 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site
text structure	expression driven by two promoters which are responsible for the synthesis of two types of transcript, and Sp1 and Sp3 are key regulators of basal transcription from both the upstream and the internal promoter

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014430 7 - 2252 NP_055245 26 219 - 2013 24161736

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine jejunum   highly Homo sapiens   intestine small intestine ileum   highly Homo sapiens   liver       highly Homo sapiens Endocrine pancreas       highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Digestive hepatocyte Homo sapiens Endocrine islet cell (alpha,beta...) Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a CIDE-N domain
	strong cell death-inducing activity in its C-terminal domain

HOMOLOGY

Homologene

FAMILY

cell death-inducing DFF45-like effector (CIDE) protein family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
text	localization to endoplasmic reticulum (ER) and lipid droplets (LD), and also localized to the Golgi apparatus

basic FUNCTION	cell death-inducing DFFA-like effector B
	putatively involved in apoptotic DNA fragmentation
	inducing cell death in a caspase-dependent manner through cytochrome c release from mitochondria
	important regulator in the development of obesity and diabetes by controlling fatty acid synthesis and VLDL secretion in hepatocytes
	is a novel regulator in controlling cholesterol homeostasis in the liver
	present in pancreatic beta-cells and involved in palmitate induced beta-cell apoptosis
	CIDEB and PLIN2 play opposing roles in controlling VLDL lipidation and hepatic lipid homeostasis
	direct requirement of CIDEB in VTV (very low density lipoprotein (VLDL) transport vesicle) formation
	potential role in VLDL transport from the ER to the Golgi
	mediates lipid droplet (LD) fusion, as well as very-low-density lipoprotein (VLDL) maturation
	play a critical role in maintaining hepatic lipid homeostasis by promoting the lipidation and maturation of VLDL particles
	plays an important role in controlling intestinal chylomicron lipidation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	DFFA/DFFB complex
	PPARGC1A plays an important role in partitioning cytoplasmic Triglycerdes toward the VLDL secretory compartments and promoting VLDL secretion via transcriptional induction of CIDEB
	interacts with APOB100 in the ER, whereas it does not interact with albumin, which is excluded from the VTV
	CIDEB is an essential cofactor for hepatitis C virus (HCV) entry into hepatocytes

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete metabolic syndrom   could serve as an important therapeutical target for the treatment of atherosclerosis and cardiovascular diseases

ANIMAL & CELL MODELS

mice with Cideb deficiency exhibited reduced intestinal chylomicron-TG secretion and increased lipid accumulation in the enterocytes