| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
|
|
in melanoma cells, and in malignant gliomas |
| constitutional
|
|
| --over
|
|
|
leads to the inhibition of NFAT (nuclear factor of activated T-cells) activity induced by Vav1, a Rac1 exchange factor |
| tumoral
|
|
| --over
|
|
|
in squamous-cell carcinomas, pancreatic, chromophobic kidney, hepatocellular or medullary breast adenocarcinomas as well as glioblastoma multiforme |
| tumoral
|
|
| --over
|
|
|
might contribute to growth and angiogenesis of gastric carcinoma (a good marker for local invasion and prognosis) |
| constitutional
|
|
| --over
|
|
in myocardium from patients with dilated cardiomyopathy  |
| constitutional
|
|
| --over
|
|
|
increases in the human left ventricle after acute myocardial infarction |
| tumoral
|
|
| --over
|
|
|
increasing levels in lung tumor epithelial cells leads to an enhancement in the metastatic potential of these cells through the upregulation of Wnt/beta-catenin signaling |
| tumoral
|
|
| --over
|
|
|
SLC3A2 and BSG were significantly upregulated in non-small cell lung cancer cells, and their expression levels were significantly correlated |
| tumoral
|
|
| --other
|
|
|
hypo-phosphorylated BSG promotes the migration and invasion of HCC cells and correlates with an unfavorable prognosis in hepatocellular carcinoma (HCC) patients |
| constitutional
|
|
|
| gain of function
|
|
during dynamic cellular events including tissue remodelling |
| tumoral
|
|
| --over
|
|
|
SLC16A44 and BSG overexpression correlated with higher PSA levels, as well as with perineural invasion and biochemical recurrence in prostate carcinoma |
